TOPMed Projects and their Parent Studies
Filter this table to display only TOPMed Projects or Parent Studies (see definitions of both). You may also filter by types of sequencing, or use the tabs at the top to filter by start phase.
Notes:
You may encounter phs links that redirect to a dbGaP error page in the table below. If so, this is because the TOPMed dbGaP study webpages do not go live until the study accession is released.
Counts of samples released in parent study-level dbGaP accessions are available in the dbGaP methods documents for freeze4 and freeze5b.
+ denotes Other Sequencing Funding
PI |
TOPMed Project![]() |
Short Name | Study Name | Approx. Sample Size | Populations | Phases Involved | Type of Omics | TOPMed Accession # |
---|---|---|---|---|---|---|---|---|
Taylor, Kent D. ; Rotter, Jerome |
AA_CAC | AA_CAC | African American Coronary Artery Calcification project | 1409 | African American families |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Ellinor, Patrick ; |
AFGen | AFGen | Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval - Atrial Fibrillation Genetics Consortium | 2799 | AF cases all EA |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Tishkoff, Sarah ; Williams, Scott |
Africa6K | Africa6K | Integrative Genomic Studies of Heart and Blood Related Traits in Africans | 7500DNA |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Mitchell, Braxton D. ; |
Amish | Amish | Genetics of Cardiometabolic Health in the Amish | 1100 | Old Order Amish large extended pedigrees |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Burchard, Esteban ; Williams, L. Keoki |
ATGC | ATGC | Asthma Translational Genomics Collaborative | 15580 WGS ph3, 3500 RNAseq ph4 |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Barnes, Kathleen ; |
BAGS | BAGS | Barbados Asthma Genetics Study | 1100 | African descent Barbados families with >40% of asthmatic members |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Gray, Kathryn J. ; Casas Romero, Juan P |
BCC-PREG | BCC-PREG | The Boston-Colombia Collaborative for Adverse Pregnancy Outcomes |
|
WGS | Please see this TOPMed Project's Parent Studies. | ||
Loos, Ruth J.F. ; Kenny, Eimear |
BioMe | BioMe | Mount Sinai BioMe Biobank | 8769 CAD, 2644 COPD |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Sankaran, Vijay G. ; |
Boston-Brazil_SCD | Boston-Brazil_SCD | Boston-Brazil Collaborative Study of Sickle Cell Disease | 958 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Fornage, Myriam ; Lloyd-Jones, Donald ; Hou, Lifang |
CARDIA | CARDIA | Whole Genome Sequence Analysis in Early Cerebral Small Vessel Disease | 3622WGS (ph3), 9480Methyl (ph5) |
|
WGS, Methylomics | Please see this TOPMed Project's Parent Studies. | |
Redline, Susan ; |
CFS | CFS | Cleveland Family Study | 1000 | African American |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Psaty, Bruce ; Tracy, Russell |
CHS | CHS | Cardiovascular Health Study | 3600 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Silverman, Edwin ; |
COPD | COPD | Genetic Epidemiology of COPD | 100WGS EOCOPD (ph1), 1885WGS COPDGene (ph1), 7400WGS (ph2), 1000WGS COPDGene (ph3), 800RNASeq COPDGene (ph4), 11,500Methyl COPDGene (ph5) | 1000 EA and 900 AA of extremely severe, early-onset COPD patients vs extreme healthy smokers (phase 1) |
|
WGS, RNASeq, Methylomics | Please see this TOPMed Project's Parent Studies. |
Weiss, Scott ; |
CRA_CAMP | CRA_CAMP | The Genetic Epidemiology of Asthma in Costa Rica and the Childhood Asthma Management Program | 1300WGS (ph1), 5319WGS (ph3), 3000Metab (ph5), 3000Methyl (ph5) | Costa Rica is a Special Hispanic population with asthma prevalence at 24% |
|
WGS, Metabolomics, Methylomics | Please see this TOPMed Project's Parent Studies. |
Sherman, Stephanie L. ; |
DS_CHD | DS_CHD | Down Syndrome Associated Atrioventricular Septal Defects: New Omic Resources | 471WGS (ph5.5) |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Silverman, Edwin ; |
ECLIPSE | ECLIPSE | Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints | 2400 (ph3) |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Ramachandran , Vasan S. ; Cupples, L. Adrienne ; Levy, Dan |
FHS | FHS | Framingham Heart Study | 4089WGS (ph1), 1861RNASeq (ph5), 3400Metab (ph5), 1900Methyl (ph5) | 3 generation EA pedigrees |
|
WGS, RNASeq, Metabolomics, Proteomics, Methylomics | Please see this TOPMed Project's Parent Studies. |
Pack, Allan ; Carrier, Julie ; Mignot, Emmanuel ; Ayas, Najib ; Magalang, Ulysses |
GEM-OSA | GEM-OSA | Genetics, Epigenetics and Metabolomics of OSA subtypes |
|
WGS, Metabolomics, Methylomics | Please see this TOPMed Project's Parent Studies. | ||
Mathias, Rasika ; |
GeneSTAR | GeneSTAR | Genetic Studies of Atherosclerosis Risk | 1400 | African American families, European families |
|
WGS | Please see this TOPMed Project's Parent Studies. |
He, Jiang ; |
GenSalt | GenSalt | Genetic Epidemiology Network of Salt Sensitivity | 1860 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Arnett, Donna K ; |
GOLDN | GOLDN | Genetics of Lipid Lowering Drugs and Diet Network | 967 | European families |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Kaplan, Robert ; North, Kari |
HCHS_SOL | HCHS_SOL | Hispanic Community Health Study - Study of Latinos | 2270 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Brown, Deborah ; |
HIPS | HIPS | Hemophilia Inhibitor PUPs study |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | ||
DeBaun, Michael ; Weiss, Mitch ; Saraf, Santosh ; Gordeuk, Victor ; Edwards, Todd ; Li, Bingshan ; Kang, Guolian ; Estepp, Jeremie ; Eapen, Mary |
HLKSCD | HLKSCD | Genetic Variation of Heart, Lung, and Kidney Disease in Sickle Cell Disease: Pre- and Post-Curative Therapies |
|
WGS | Please see this TOPMed Project's Parent Studies. | ||
Arnett, Donna K ; |
HyperGEN_GENOA | HyperGEN_GENOA | Hypertension Genetic Epidemiology Network and Genetic Epidemiology Network of Arteriopathy | 3161 | African American families |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Schwartz, David ; Fingerlin, Tasha |
IPF | IPF | Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis | 1500 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Correa, Adolfo ; Raffield, Laura |
JHS | JHS | Jackson Heart Study | 3500 | African American mixed family and population based |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Silverman, Edwin ; |
LTRC | LTRC | Lung Tissue Research Consortium | 1548WGS (ph4), 1648RNASeq (ph4), 3196Methyl (ph5) |
|
WGS, RNASeq, Methylomics | Please see this TOPMed Project's Parent Studies. | |
Walter, Matthew ; Miller, Christopher ; Lindsley, Coleman ; Padron, Eric ; Goll, Johannes ; Saber, Wael |
MDS | MDS | Genomics of Myelodysplastic Syndromes |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | ||
Rotter, Jerome ; Rich, Stephen |
MESA | MESA | Multi-Ethnic Study of Atherosclerosis | 4595 | multi-ethnic populations |
|
WGS, RNASeq, Metabolomics, Proteomics, Methylomics | Please see this TOPMed Project's Parent Studies. |
Konkle, Barbara ; Johnsen, Jill |
MLOF | MLOF | My Life, Our Future: Genotyping for Progress in Hemophilia | 2188 (ph2), 2959 (ph3) |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Haas, David ; Parker, Cora ; McNeil, Becky |
nuMoM2b-HHS | nuMoM2b-HHS | nuMoM2b-Heart Health Study |
|
WGS | Please see this TOPMed Project's Parent Studies. | ||
Ashley-Koch, Allison ; Telen, Marilyn |
OMG_SCD | OMG_SCD | Outcome Modifying Genes in Sickle Cell Disease | 675 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Gelb, Bruce ; Seidman, Christine |
PCGC_CHD | PCGC_CHD | Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank | 3230WGS (ph4), 308RNASeq (ph4) |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Burchard, Esteban ; Hernandez, Ryan |
PGX_Asthma | PGX_Asthma | Pharmacogenomics of Bronchodilator Response in Minority Children with Asthma | 1500 | 500AA, 500 Puerto Rican, and 500 Mexican of extremely non-responding asthma patients. |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Boerwinkle, Eric ; Pace, Betty Sue ; Sheehan, Vivien |
PharmHU | PharmHU | The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease | 1454 |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Saleheen, Danish ; |
PROMIS | PROMIS | Pakistan Risk of Myocardial Infarction Study | 4,211 (WGS ph4), 3,750 (WGS ph+ TOPMed & CCDG co-funded) | South Asian ancestry from Pakistan |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Nekhai, Sergei ; |
PUSH_SCD | PUSH_SCD | Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease | 450 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Erzurum, Serpil ; Barnard, John ; Beck, Gerald ; Comhair, Suzy ; Geraci, Mark |
PVDOMICS | PVDOMICS | Pulmonary Vascular Disease Omics Analyses |
|
WGS, RNASeq, Methylomics | Please see this TOPMed Project's Parent Studies. | ||
Custer, Brian ; Kelly, Shannon |
REDS-III_Brazil | REDS-III_Brazil | Recipient Epidemiology and Donor Evaluation Study-III | 2809 | Brazilian |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Blangero, John ; Curran, Joanne |
SAFS | SAFS | San Antonio Family Studies | 1142 | Mexican American in SAFHS extended pedigrees |
|
WGS | Please see this TOPMed Project's Parent Studies. |
McGarvey, Stephen ; |
Samoan | Samoan | Samoan Adiposity Study | 384 (ph1), 912 (ph2) | Samoan |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Montgomery, Courtney ; |
Sarcoidosis | Sarcoidosis | Genetics of Sarcoidosis in African Americans | 650 | African American families |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Meyers, Deborah A ; |
SARP | SARP | Severe Asthma Research Program | 1900 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Wu, Joseph ; Bustamante, Carlos |
SCVI | SCVI | Stanford Cardiovascular Institute iPSC Biobank Study | 1500WGS, 450RNAseq |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Casella, James ; |
SIT_SCD | SIT_SCD | Silent Infarction Transfusion (SIT) Sickle Cell Disease (SCD) |
|
WGS | Please see this TOPMed Project's Parent Studies. | ||
Meyers, Deborah A ; |
SPIROMICS | SPIROMICS | SubPopulations and InteRmediate Outcome Measures In COPD Study | 2981 WGS, 5253 RNAseq |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Rotter, Jerome ; Chen, Yii-Der Ida |
THRV | THRV | Taiwan Study of Hypertension using Rare Variants | 2585 | Taiwan Chinese families |
|
WGS | Please see this TOPMed Project's Parent Studies. |
Taylor, Matthew ; Mestroni, Luisa ; Graw, Sharon |
TOPCHeF | TOPCHeF | Trans-Omics for Precision Medicine for Congestive Heart Failure | 1078RNASeq, 1078WGS |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Seidman, Jonathan ; Seidman, Christine |
UNID_CM | UNID_CM | The Genetic Causes of Unexplained Cardiomyopathies | 1050WGS, 400RNAseq |
|
WGS, RNASeq | Please see this TOPMed Project's Parent Studies. | |
Boerwinkle, Eric ; |
VTE | VTE | Venous Thromboembolism project | 6000 |
|
WGS, Methylomics | Please see this TOPMed Project's Parent Studies. | |
Gladwin, Mark ; Zhang, Yingze |
walk_PHaSST | walk_PHaSST | Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy | 597 |
|
WGS | Please see this TOPMed Project's Parent Studies. | |
Kooperberg, Charles ; Reiner, Alex |
WHI | WHI | Women's Health Intiative | 11,100WGS, 1400RNAseq (ph4), 1400Metab (ph5), 1400Methyl (ph5) |
|
WGS, RNASeq, Metabolomics, Proteomics, Methylomics | Please see this TOPMed Project's Parent Studies. |