TOPMed Projects and their Parent Studies

Filter this table to display only TOPMed Projects or Parent Studies (see definitions of both). You may also filter by types of sequencing, or use the tabs at the top to filter by start phase.

Notes:
You may encounter phs links that redirect to a dbGaP error page in the table below. If so, this is because the TOPMed dbGaP study webpages do not go live until the study accession is released.

Counts of samples released in parent study-level dbGaP accessions are available in the dbGaP methods documents for freeze4 and freeze5b.

+ denotes Other Sequencing Funding

PI TOPMed Project Short Namesort descending Study Name Approx. Sample Size Populations Phases Involved Type of Omics TOPMed Accession #
Sinner, Mortiz ;
Kaab, Stefan 		AFGen AFLMU Atrial Fibrillation Biobank Ludwig Maximilian University Study 248 co-funded, 102 phase 2.5
  • Other Funding
 WGS phs001543
Tishkoff, Sarah ;
Williams, Scott 		Africa6K Africa6K Integrative Genomic Studies of Heart and Blood Related Traits in Africans
  • 4
 WGS phs002194
Mitchell, Braxton D. ;
 Amish Amish Genetics of Cardiometabolic Health in the Amish 1100 Old Order Amish large extended pedigrees
  • 1
 WGS phs000956
Boerwinkle, Eric ;
 VTE ARIC Atherosclerosis Risk in Communities Study VTE cohort 3937
  • 2
  • 6
 WGS, Methylomics phs001211
Alonso, Alvaro ;
Arking, Dan 		AFGen ARIC AFGen Atherosclerosis Risk in Communities Study 84
  • 1
 WGS phs001211
Fatkin, Diane ;
 AFGen AustralianFamilialAF Molecular Mechanisms of Inherited Cardiomyopathies and Arrhythmias in the Australian Familial AF Study 120
  • 1
 WGS phs001435
Barnes, Kathleen ;
 BAGS BAGS New Approaches for Empowering Studies of Asthma in Populations of African Descent - Barbados Asthma Genetics Study 1100 African descent Barbados families with >40% of asthmatic members
  • 1
 WGS phs001143
Gray, Kathryn J. ;
Casas Romero, Juan P 		BCC-PREG BCC-PREG The Boston-Colombia Collaborative for Adverse Pregnancy Outcomes
  • 7
 WGS
Loos, Ruth J.F. ;
Kenny, Eimear 		AFGen BioMe AFGen Mount Sinai BioMe Biobank
  • Other Funding
 WGS phs001644
Shoemaker, M. Benjamin ;
Roden, Dan 		AFGen BioVU_AF The Vanderbilt University BioVU Atrial Fibrillation Genetics Study
  • Other Funding
 WGS phs001624
Sankaran, Vijay G. ;
 Boston-Brazil_SCD Boston-Brazil_SCD Boston-Brazil Collaborative Study of Sickle Cell Disease 958
  • 2
  • 5
 WGS phs001599
Weiss, Scott T ;
 CRA_CAMP CAMP Childhood Asthma Management Program ???WGS (ph3), 1700Metab (ph5), 1700Methyl (ph5)
  • 3
  • 5
 WGS, Metabolomics, Methylomics phs001726
Fornage, Myriam ;
Lloyd-Jones, Donald ;
Hou, Lifang 		CARDIA CARDIA Coronary Artery Risk Development in Young Adults 3622WGS (ph3), 9480Methyl (ph5)
  • 3
  • 5
 WGS, Methylomics phs001612
Martinez, Fernando ;
 ATGC CARE_BADGER Childhood Asthma Research and Education Network: Best Add-on Therapy Giving Effective Responses
  • 3
 WGS phs001728
Martinez, Fernando ;
 ATGC CARE_CLIC Childhood Asthma Research and Education Network: Characterizing the Response to a Leuikotriene Receptor Agonis and an Inhaled Corticosteroid 219
  • 3
 WGS phs001729
Martinez, Fernando ;
 ATGC CARE_PACT Childhood Asthma Research and Education Network: Pediatric Asthma Controller Trial
  • 3
 WGS phs001730
Martinez, Fernando ;
 ATGC CARE_TREXA Childhood Asthma Research and Education Network: Treating Children to Prevent Exacerbations of Asthma
  • 3
 WGS phs001732
Kraus , William ;
Sun, Albert 		AFGen CATHGEN The Duke CATHeterization GENetics Study
  • Other Funding
 WGS phs001600
Chung, Mina ;
Barnard, John 		AFGen CCAF Cleveland Clinic Atrial Fibrillation Study 365
  • 1
 WGS phs001189
Redline, Susan ;
 CFS CFS Cleveland Family Study - WGS Collaboration 1000 African American
  • 1
 WGS phs000954
Gilliland, Frank ;
 ATGC ChildrensHS_GAP Children's Health Study: Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma
  • 3
 WGS phs001602
Gilliland, Frank ;
 ATGC ChildrensHS_IGERA Children's Health Study: Integrative Genomics and Environmental Research of Asthma 231
  • 3
 WGS phs001603
Gilliland, Frank ;
 ATGC ChildrensHS_MetaAir Children's Health Study: Effects of Air Pollution on the Development of Obesity in Children
  • 3
 WGS phs001604
Kumar, Rajesh ;
 ATGC CHIRAH Genetics Sub-Study of Chicago Initiative to Raise Asthma Health Equity 318
  • 3
 WGS phs001605
Psaty, Bruce ;
Tracy, Russell 		CHS CHS Cardiovascular Health Study 3600
  • 3
 WGS phs001368
Heckbert, Susan ;
 VTE CHS VTE Cardiovascular Health Study 71
  • 2
 WGS phs001368
Silverman, Edwin ;
 COPD COPDGene Genetic Epidemiology of COPD Study 1885 (ph1), 7400 (ph2), 1000 (ph3), 800RNA (ph4), 11,500Methyl (ph5) African American, non-Hispanic White
  • 1
  • 2
  • 3
  • 4
  • 5
  • Other Funding
 WGS, RNASeq, Methylomics phs000951
Silverman, Edwin ;
 COPDMet COPDGene COPDMet Genetic Epidemiology of COPD Study
  • 7
 Metabolomics phs000951
Weiss, Scott T ;
 CRA_CAMP CRA The Genetic Epidemiology of Asthma in Costa Rica - Asthma in Costa Rica cohort 1300WGS (ph1), 1300Metab (ph5), 1300Methyl (ph5) Costa Rica is a Special Hispanic population with asthma prevalence at 24%
  • 1
  • 3
  • 5
 WGS, Metabolomics, Methylomics phs000988
Carrier, Julie ;
 GEM-OSA CSCN-OSA Canadian Sleep and Circadian Network - Obstructive Sleep Apnea Project
  • 7
 WGS, Metabolomics, Methylomics
Mohanty, Sanghamitra ;
Natale, Andrea 		AFGen DECAF Determining the association of chromosomal variants with non-PV triggers and ablation-outcome in DECAF
  • 1
 WGS phs001546
Palmer, Nicholette ;
Bowden, Donald W. 		AA_CAC DHS Diabetes Heart Study
  • 2
 WGS phs001412
Silverman, Edwin ;
 ECLIPSE ECLIPSE Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points 2400 (ph3)
  • 3
 WGS phs001472
Esko, Tonu ;
 AFGen EGCUT Estonian Genome Center 2900WGS
  • Other Funding
 WGS phs001606
Silverman, Edwin ;
 COPD EOCOPD Boston Early-Onset COPD Study 100
  • 1
 WGS phs000946
Province, Mike ;
Lenzini, Petra 		AA_CAC FamHS Family Heart Study
  • 2
 WGS sequencing not planned
Ramachandran, Vasan S. ;
Levy, Dan ;
Cupples, L. Adrienne 		FHS FHS Framingham Heart Study 4089WGS (ph1), 1861RNASeq (ph5), 3400Metab (ph5), 1900Methyl (ph5) 3 generation EA pedigrees
  • 1
  • 5
  • Other Funding
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics phs000974
Benjamin, Emelia ;
Lunetta, Kathryn 		AFGen FHS AFGen Framingham Heart Study 111
  • 1
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics phs000974
Burchard, Esteban ;
 ATGC GALAI ATGC Gene-Environment, Admixture and Latino Asthmatics Study I Asthma Mexican/Other Latino 465, Puerto Rican 620
  • 3
 WGS phs001542
Burchard, Esteban ;
 PGX_Asthma GALAII Gene-Environment, Admixture and Latino Asthmatics Study 994 Latino
  • 1
  • Other Funding
 WGS phs000920
Burchard, Esteban ;
 ATGC GALAII ATGC ATGC Gene-Environment, Admixture and Latino Asthmatics Study II Asthma Mexican/Other Latino 2383, Puerto Rican 2519
  • 3
  • 4
 WGS, RNASeq phs000920
Hakonarson, Hakon ;
 ATGC GCPD-A Genetics of Complex Pediatric Disorders - Asthma 4000
  • 3
 WGS phs001661
Christophersen, Ingrid Elisabeth ;
 AFGen GENAF The GENetics in Atrial Fibrillation Study
  • Other Funding
 WGS phs001547
Mathias, Rasika ;
 GeneSTAR GeneSTAR Genetic Studies of Atherosclerosis Risk 1400 African American families, European families
  • 2
  • Other Funding
 WGS phs001218
Mathias, Rasika ;
 AA_CAC GeneSTAR AA_CAC Genetic Studies of Atherosclerosis Risk African American families, European families
  • 2
 WGS phs001218
Kardia, Sharon ;
Smith, Jennifer 		HyperGEN_GENOA GENOA Genetic Epidemiology Network of Arteriopathy African American families
  • 2
 WGS phs001345
Peyser, Patricia ;
Bielak, Larry 		AA_CAC GENOA AA_CAC Genetic Epidemiology Network of Arteriopathy
  • 2
 WGS phs001345
He, Jiang ;
 GenSalt GenSalt Genetic Epidemiology Network of Salt Sensitivity 1860
  • 2
 WGS phs001217
Rienstra, Michiel ;
 AFGen GGAF Groningen Genetics of Atrial Fibrillation Study
  • Other Funding
 WGS phs001725
Arnett, Donna K ;
 GOLDN GOLDN Genetics of Lipid Lowering Drugs and Diet Network 967 European families
  • 2
 WGS phs001359
Kaplan, Robert ;
North, Kari 		HCHS_SOL HCHS_SOL Hispanic Community Health Study - Study of Latinos 2270
  • 3
 WGS phs001395
Brown, Deborah ;
 HIPS HIPS Hemophilia Inhibitor PUPs study
  • 7
 WGS, RNASeq phs002302
DeBaun, Michael ;
Estepp, Jeremie ;
Gordeuk, Victor ;
Li, Bingshan ;
Saraf, Santosh ;
Eapen, Mary ;
Kang, Guolian ;
Edwards, Todd ;
Weiss, Mitch 		HLKSCD HLKSCD Genetic Variation of Heart, Lung, and Kidney Disease in Sickle Cell Disease: Pre- and Post-Curative Therapies
  • 7
 WGS
Heckbert, Susan ;
 AFGen HVH Heart and Vascular Health Study 79
  • 1
 WGS phs000993
Smith, Nicholas ;
 VTE HVH VTE Heart and Vascular Health Study 637
  • 2
 WGS phs000993
Arnett, Donna K ;
 HyperGEN_GENOA HyperGEN Hypertension Genetic Epidemiology Network African American families
  • 2
 WGS phs001293
Cutler, Michael ;
Knight, Stacey 		AFGen INSPIRE_AF Intermountain Heart Study
  • Other Funding
 WGS phs001545
Schwartz, David ;
Fingerlin, Tasha 		IPF IPF Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis 1500
  • 3
  • 7
 WGS phs001607
Correa, Adolfo ;
Raffield, Laura 		JHS JHS Jackson Heart Study 3500 AA mixed family and population based
  • 1
 WGS phs000964
Nazarian, Saman ;
 AFGen JHU_AF The Johns Hopkins University School of Medicine Atrial Fibrillation Genetics Study
  • Other Funding
 WGS phs001598
Silverman, Edwin ;
 LTRC LTRC Lung Tissue Research Consortium 1548WGS (ph4), 1648RNASeq (ph4), 3196Methyl (ph5)
  • 4
  • 5
 WGS, RNASeq, Methylomics phs001662
de Andrade, Mariza ;
 VTE Mayo_VTE Mayo Clinic Venous Thromboembolism Study 1355
  • 2
 WGS phs001402
Walter, Matthew ;
 MDS MDS Genomics of Myelodysplastic Syndromes
  • 7
 WGS, RNASeq phs002360
Rotter, Jerome ;
Rich, Stephen 		MESA MESA Multi-Ethnic Study of Atherosclerosis 4595 multi-ethnic populations
  • 2
  • 6
  • Other Funding
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics phs001416
Rotter, Jerome ;
 AA_CAC MESA AA_CAC Multi-Ethnic Study of Atherosclerosis Family cohort
  • 2
 WGS phs001416
Ellinor, Patrick ;
 AFGen MGH_AF Massachusetts General Hospital Atrial Fibrillation Study 688
  • 1
 WGS phs001062
McManus, David ;
 AFGen miRhythm Defining time-dependent genetic and transcriptomic responses to cardiac injury among patients with arrhythmias
  • 1
 WGS phs001434
Konkle, Barbara ;
Johnsen, Jill 		MLOF MLOF My Life, Our Future: Genotyping for Progress in Hemophilia 2188 (ph2), 2959 (ph3)
  • 2
  • 3
  • 6
 WGS, RNASeq phs001515
Smith, Gustav ;
 AFGen MPP Malmo Preventative Project 250WGS (ph5)
  • Other Funding
 WGS phs001544
Haas, David M. ;
Parker, Cora 		nuMoM2b-HHS nuMoM2b-HHS nuMoM2b-Heart Health Study
  • 7
 WGS phs002339
Ashley-Koch, Allison ;
Telen, Marilyn 		OMG_SCD OMG_SCD Outcome Modifying Genes in Sickle Cell Disease 675
  • 2
 WGS phs001608
Lubitz, Steven ;
 AFGen Partners Partners Healthcare Biorepository 128
  • 1
 WGS phs001024
Gelb, Bruce ;
Seidman, Christine 		PCGC_CHD PCGC_CHD Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank 3230WGS (ph4), 308RNASeq (ph4)
  • 4
 WGS, RNASeq phs001735
Sherman, Stephanie L. ;
 DS_CHD PCGC_DS_CHD Down Syndrome Associated Atrioventricular Septal Defects: New Omic Resources 471WGS (ph5.5)
  • Other Funding
 WGS phs001735
Boerwinkle, Eric ;
Pace, Betty Sue ;
Sheehan, Vivien 		PharmHU PharmHU The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease 1454
  • 2
  • 6
 WGS, RNASeq phs001466
Aldred, Micheala ;
Erzurum, Serpil ;
Geraci, Mark 		PVDOMICS PHBI Pulmonary Hypertension Breakthrough Initiative phs002358
Martinez, Fernando ;
 ATGC PIMA Pathways to Immunologically Mediated Asthma 74
  • 3
 WGS phs001727
Rader, Daniel ;
Damrauer, Scott 		AFGen PMBB_AF Early-onset Atrial Fibrillation in the Penn Medicine BioBank Cohort
  • Other Funding
 WGS phs001601
Saleheen, Danish ;
 PROMIS PROMIS Pakistan Risk of Myocardial Infarction Study 4,211 (WGS ph4), 3,750 (WGS ph+ TOPMed & CCDG co-funded)
  • 4
  • Other Funding
 WGS phs001569
Nekhai, Sergei ;
 PUSH_SCD PUSH_SCD Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease 450
  • 2
 WGS phs001682
Erzurum, Serpil ;
Comhair, Suzy ;
Barnard, John ;
Geraci, Mark ;
Beck, Gerald 		PVDOMICS PVDOMICS Pulmonary Vascular Disease Omics Analyses
  • 6
 WGS, RNASeq, Methylomics phs002451
Custer, Brian ;
Kelly, Shannon 		REDS-III_Brazil REDS-III_Brazil Recipient Epidemiology and Donor Evaluation Study-III 2809 Brazilian
  • 2
 WGS phs001468
Blangero, John ;
Curran, Joanne 		SAFS SAFS Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk - San Antonio Family Studies 1142 Mexican American in SAFHS extended pedigrees
  • 1
 WGS phs001215
Burchard, Esteban ;
 PGX_Asthma SAGE Study of African Americans, Asthma, Genes and Environment 490 African American
  • 1
  • Other Funding
 WGS phs000921
Burchard, Esteban ;
 ATGC SAGE ATGC ATGC Study of African Americans, Asthma, Genes and Environment 2270
  • 3
  • 4
 WGS, RNASeq phs000921
McGarvey, Stephen ;
 Samoan Samoan Samoan Adiposity Study 384 (ph1), 912 (ph2) Samoan
  • 1
  • 2
 WGS phs000972
Williams, L. Keoki ;
 ATGC SAPPHIRE_asthma Study of Asthma Phenotypes & Pharmacogenomic Interactions by Race-Ethnicity African American 4696, Mexican/Other Latino 236
  • 3
 WGS phs001467
Montgomery, Courtney ;
 Sarcoidosis Sarcoidosis Genetics of Sarcoidosis in African Americans 650 African American families
  • 2
 WGS phs001207
Meyers, Deborah A ;
 SARP SARP Severe Asthma Research Program 1900
  • 2
 WGS phs001446
Wu, Joseph ;
Bustamante, Carlos 		SCVI SCVI Stanford Cardiovascular Institute iPSC Biobank Study 1500WGS, 450RNAseq
  • 5
 WGS, RNASeq phs002338
Casella, James ;
 SIT_SCD SIT_SCD Silent Infarction Transfusion (SIT) Sickle Cell Disease (SCD)
  • 2
 WGS sequencing not planned
Meyers, Deborah A ;
 SPIROMICS SPIROMICS SubPopulations and InteRmediate Outcome Measures In COPD Study 2981 WGS, 5253 RNAseq
  • 4
 WGS, RNASeq phs001927
Meyers, Deborah A ;
 COPDMet SPIROMICS COPDMet SubPopulations and InteRmediate Outcome Measures In COPD Study
  • 7
 Metabolomics phs001927
Rotter, Jerome ;
Chen, Yii-Der Ida 		THRV THRV Taiwan Study of Hypertension using Rare Variants 2585 Taiwan Chinese families
  • 2
 WGS phs001387
Taylor, Matthew ;
Mestroni, Luisa ;
Graw, Sharon 		TOPCHeF TOPCHeF Trans-Omics for Precision Medicine for Congestive Heart Failure 1078RNASeq, 1078WGS
  • 4
 WGS, RNASeq phs002038
Marcus, Gregory ;
 AFGen UCSF_AF UCSF_AF
  • Other Funding
 WGS phs001933
Seidman, Jonathan ;
Seidman, Christine 		UNID_CM UNID_CM The Genetic Causes of Unexplained Cardiomyopathies 1050WGS, 400RNAseq
  • 5
 WGS, RNASeq phs002382
Gelb, Bruce ;
Seidman, Christine 		UNID_CM UNID_CM PCGC_CHD Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank
  • 5
 WGS phs001735
Shoemaker, M. Benjamin ;
 AFGen VAFAR Vanderbilt Atrial Fibrillation Ablation Registry 122
  • 1
 WGS phs000997
Darbar, Dawood ;
 AFGen VU_AF Vanderbilt Genetic Basis of Atrial Fibrillation 1157
  • 1
 WGS phs001032
Gladwin, Mark ;
Zhang, Yingze 		walk_PHaSST walk_PHaSST Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy 597
  • 2
 WGS phs001514
Albert, Christine ;
Chasman, Daniel 		AFGen WGHS Women's Genome Health Study 118
  • 1
 WGS phs001040
Kooperberg, Charles ;
Reiner, Alex 		WHI WHI Women's Health Initiative 11,100WGS, 1400RNA (ph4), 1400Metab (ph5), 1400Methyl (ph5)
  • 2
  • 4
  • 5
  • 7
 WGS, RNASeq, Metabolomics, Proteomics, Methylomics phs001237
103 studies