Children's Health Study: Effects of Air Pollution on the Development of Obesity in Children

Project:

PI: 
Frank Gilliland
Starting Phase: 
Phase 3
Phases Involved: 
3
Phenotype Liaison: 
Data Set contact(s): 
Short Name: 
ChildrensHS_MetaAir
Sequencing Center(s) Phase 3: 
Northwest Genomics Center
Type of Sequencing: 
WGS
Sequencing External Funding: 
TOPMed Accession #: 
Description: 

The Effects of Air Pollution on the Development of Obesity in Children (Meta-AIR) study was proposed to study a subset of the Children’s Health Study (CHS) participants representing the extremes of long-term traffic-related air pollution exposure occurring in Southern California CHS communities. The primary aim of the Meta-AIR study was to investigate whether lifetime exposure to air pollution increases risk for obesity and metabolic dysfunction at 17-18 years of age. The study participants were enrolled from the original southern California Children’s Health Study (CHS) with Institutional Review Board oversight and receipt of informed consent from all participants. A total of 54 Hispanic White participants (15 asthma cases and 39 controls) were included in the TOPMed project.