Children's Health Study: Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma

Project:

PI: 
Frank Gilliland
Starting Phase: 
Phase 3
Phases Involved: 
3
Phenotype Liaison: 
Data Set contact(s): 
Short Name: 
ChildrensHS_GAP
Omics Center(s) Phase 3: 
Northwest Genomics Center
Type of Omics: 
WGS
External Funding: 
TOPMed Accession #: 
Description: 

The Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma (GAP) study was proposed to use an innovative genetics approach in mice and humans to identify novel variants that interact with traffic-related pollutant exposures to affect lung function phenotypes and the risk of childhood asthma. The study participants were enrolled from the original southern California Children’s Health Study (CHS) with Institutional Review Board oversight and receipt of informed consent from all participants. In the TOPMed project, seven Hispanic White participants who did not have asthma history were included in the WGS analysis.