Cleveland Family Study - WGS Collaboration

Institution(s): 
Brigham & Women's Hospital
Approx. Sample Size: 
1000
Populations: 

African American

Project:

  • CFS
Disease/Phenotype: 

Obstructive Sleep Apnea

PI: 
Susan Redline
Contact: 
mrueschman@partners.org
Omics Center(s) Phase 1: 
Northwest Genomics Center
NIH Program Officer: 
ganw2@nhlbi.nih.gov
Starting Phase: 
Phase 1
Phases Involved: 
1
Phenotype Liaison: 
jlee250@bwh.harvard.edu
mrueschman@partners.org
Data Set contact(s): 
bcade@bwh.harvard.edu
sredline1@rics.bwh.harvard.edu
Short Name: 
CFS
Type of Omics: 
WGS
External Funding: 
TOPMed Accession #: 
phs000954
Omics Center(s) Other Phase (specify): 
Northwest Genomics Center
Specify the TOPMed Phase for the Omics Center(s) selected above: 
3.5
Description: 

The Cleveland Family Study (CFS) was designed to examine the genetic basis of sleep apnea in 2,534 African-American and European-American individuals from 356 families. Index probands with confirmed sleep apnea were recruited from sleep centers in northern Ohio, supplemented with additional family members and neighborhood control families [{Redline1995}]. Four visits occurred between 1990 and 2006; in the first 3, data were collected in participants’ homes while the last occurred in a clinical research center (2000 - 2006). Measurements included sleep apnea monitoring, blood pressure, anthropometry, spirometry and other related phenotypes. Blood samples (overnight fasting, before bed and following an oral glucose tolerance test), nasal and oral ultrasound, and ECG were also obtained during the 4th exam. Institutional Review Board approval and signed informed consent was obtained for all participants.