Cleveland Family Study - WGS Collaboration

Institution(s): 
Brigham & Women's Hospital
Approx. Sample Size to be Sequenced: 
1000
Populations: 

African American

Project:

Disease/Phenotype: 

Obstructive Sleep Apnea

PI: 
Susan Redline
Sequencing Center(s) Phase 1: 
Northwest Genomics Center
NIH Program Officer: 
Starting Phase: 
Phase 1
Phases Involved: 
1
Short Name: 
CFS
Type of Sequencing: 
WGS
Sequencing External Funding: 
TOPMed Accession #: 
Sequencing Center(s) Other Phase (specify): 
Northwest Genomics Center
Specify the TOPMed Phase for the Sequencing Center(s) selected above: 
3.5
Description: 

The Cleveland Family Study (CFS) was designed to examine the genetic basis of sleep apnea in 2,534 African-American and European-American individuals from 356 families. Index probands with confirmed sleep apnea were recruited from sleep centers in northern Ohio, supplemented with additional family members and neighborhood control families [{Redline1995}]. Four visits occurred between 1990 and 2006; in the first 3, data were collected in participants’ homes while the last occurred in a clinical research center (2000 - 2006). Measurements included sleep apnea monitoring, blood pressure, anthropometry, spirometry and other related phenotypes. Blood samples (overnight fasting, before bed and following an oral glucose tolerance test), nasal and oral ultrasound, and ECG were also obtained during the 4th exam. Institutional Review Board approval and signed informed consent was obtained for all participants.